目的：探讨不同比例东氯合剂对小鼠和大鼠的急性毒性。方法：用Ｂｌｉｓ法和Ｂｒｏｗｎｌｅ序贯法分别测定不同比例东莨菪碱与氯丙嗪组合成不同比例东氯合剂后对小鼠、大鼠的半数致死量（ＬＤ５０）。结果：不同比例东氯合剂对小鼠的（ＬＤ５０）分别为０∶１（３６７±０３５ｍＬ·ｋｇ－１），０３３∶１（４０６±０３０ｍＬ·ｋｇ－１），１∶１（４２６±０２４ｍＬ·ｋｇ－１），３∶１（３８８±０２８ｍＬ·ｋｇ－１）。同时东氯合剂（１∶１）对雌性小鼠ＬＤ５０为３９３±０２２ｍＬ·ｋｇ－１而对雄性小鼠ＬＤ５０为４５８±０３３ｍＬ·ｋｇ－１；对大鼠的ＬＤ５０为３８６±０３０ｍＬ·ｋｇ－１。结论：东氯合剂（１∶１）即东莨菪碱（０３ｍｇ·ｍＬ－１）和氯丙嗪（１２５ｍｇ·ｍＬ－１）毒性最低，且对雌性小鼠毒性大于雄性。 Objective: To investigate the acute toxicity of different proportions of dongluk mixture to mice and rats. Methods: The LD50 of mice and rats were determined by Blis method and Brownle sequential method respectively after the different proportions of scopolamine and chlorpromazine were combined into different ratios. Results: The LD50 of different proportions of Donglu mixture were 0: 1 (367 ± 035mL · kg-1), 033:1 (406 ± 030mL · kg-1 ), 1: 1 (426 ± 024mL · kg-1), 3:1 (388 ± 028mL · kg-1). At the same time, the LD50 of Dongqing mixture (1: 1) in female mice was 393 ± 022 mL · kg-1 and that of male mice was 458 ± 033 mL · kg-1. The LD50 3  86 ± 0  30mL · kg-1. CONCLUSION: Donglian mixture (1: 1), scopolamine (03 mg · mL-1) and chlorpromazine (125 mg · mL-1) have the lowest toxicity and toxicity to female mice than male ones.