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钙拮抗剂又称慢通道阻滞剂、钙流入阻滞剂。钙拮抗剂的发展成为七十年代以来心血管药物治疗的重要进展之一。Fleckens-tein于1963年在鉴定两种扩冠剂,异搏停与双苯丙胺时发现此二药均能特异地抑制心肌兴奋-收缩耦联,其作用与单纯除去心肌中钙的效应相似。当加入钙、β受体兴奋剂或强心甙时,此作用即消失。由此推测此二药的共同作用可能干扰钙在心肌兴奋-收缩耦联中的调节功能,从而提出了钙拮抗的机制.1968年,1969年又先后鉴定了D~(600)硝苯吡啶和Niludipine,证明也能抑制心肌兴奋-收缩耦联。1969年他宣布一类心肌兴奋收缩耦联的特异性抑制剂被发现,命名为钙拮抗
Calcium antagonists, also known as slow channel blockers, calcium influx blockers. The development of calcium antagonists has become one of the important advances in the treatment of cardiovascular drugs since the seventies. Fleckens-tein in 1963 in the identification of two kinds of crown-expanding agent, verapamil and amphetamine found that these two drugs can specifically inhibit cardiac excitation - contraction coupling, its role and simply remove the effect of calcium in the myocardium is similar. When adding calcium, beta receptor agonists or cardiac glycosides, this effect disappears. It is speculated that the synergistic effect of these two drugs may interfere with the regulatory function of calcium in cardiac excitatory-contractile coupling, and thus put forward the mechanism of calcium antagonism.In 1968, 1969, we identified D ~ (600) nifedipine and Niludipine, proved to also inhibit cardiac excitation - contraction coupling. In 1969 he announced that a specific inhibitor of cardiac contractile coupling was found, named calcium antagonist