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目的探讨血小板活化及其相关炎症因子在伴有喘息症状儿童肺炎中的作用。方法住院33例肺炎患儿分为喘息症状(A组,21例)和无喘息症状(B组,12例)两组;对照(C,10例)组为健康儿童。采用流式细胞术检测外周血血小板膜CD62P+,ELISA检测血浆P-选择素以及转化生长因子β(TGF-β)的水平。结果 A、B组血小板膜CD62P表达均高于C组(P<0.05)。胶原刺激前三组P-选择素和TGF-β差异无统计学意义;胶原刺激后三组P-选择素和TGF-β均增高,A、B组显著增高于C组,且A组增高幅度显著高于B组。结论对喘息患儿进行早期干预血小板活化治疗可望成为预防哮喘的一种新途径。
Objective To investigate the role of platelet activation and its associated inflammatory cytokines in pneumonia associated with asthmatic children. Methods 33 children with pneumonia were divided into two groups: asthmatic symptom (group A, 21 cases) and no wheezing symptom (group B, n = 12). Control group (group C, n = 10) was healthy children. The peripheral blood platelet membrane CD62P + was detected by flow cytometry. The levels of plasma P-selectin and TGF-β were detected by ELISA. Results The platelet membrane CD62P in groups A and B were higher than those in group C (P <0.05). There was no significant difference in P-selectin and TGF-β between the three groups before collagen stimulation. The levels of P-selectin and TGF-β in the three groups were increased after collagen stimulation, while in group A and B were significantly higher than those in group C Significantly higher than the B group. Conclusions Early treatment of wheezy children with platelet activation is expected to become a new way to prevent asthma.