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目的:评价乌司他丁与生长抑素对急性重症胰腺炎的老年患者疗效及其对血清IL-6、IL-8和TNF-α水平的影响。方法:选取2013年12月—2015年11月间收治的确诊为急性重症胰腺炎的老年患者81例纳入研究,并将其随机分为对照组40例和治疗组41例;对照组患者给予按《急性胰腺炎诊治指南》要求采用常规治疗,治疗组患者则给予生长抑素与乌司他丁治疗;比较治疗前及治疗后7 d血淀粉酶(AMY)、谷丙转氨酶(ALT)、肌酐(Scr)等肝肾功能指标,以及肿瘤坏死因子(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)等炎症因子的改善情况和两组患者治疗后的临床症状各体征消失时间。结果:治疗组患者治疗后ALT、Scr、AMY、TNF-α、IL-8和IL-6等指标的平均水平均低于对照组(P<0.05),腹痛、腹胀、恶心呕吐、腹膜刺激征等症状各体征消失时间均短于对照组(P<0.05)。结论:采用乌司他丁与生长抑素治疗老年患者疗效较显著,可缩短病程,抑制炎症因子水平,其疗效优于常规治疗方案的治疗。
Objective: To evaluate the curative effect of ulinastatin and somatostatin on senile patients with severe acute pancreatitis and its effects on serum IL-6, IL-8 and TNF-α levels. Methods: A total of 81 elderly patients with acute severe pancreatitis admitted from December 2013 to November 2015 were enrolled and randomly divided into control group (40 cases) and treatment group (41 cases). Patients in the control group The Guidelines for the Diagnosis and Treatment of Acute Pancreatitis require routine treatment, and the patients in the treatment group are treated with somatostatin and ulinastatin. The levels of amylase, alanine aminotransferase (ALT), creatinine (Scr) and other indicators of liver and kidney function, as well as the improvement of inflammatory factors such as tumor necrosis factor (TNF-α), interleukin-8 (IL-8) and interleukin-6 (IL-6) Each symptom disappears time. Results: The mean levels of ALT, Scr, AMY, TNF-α, IL-8 and IL-6 in the treatment group were lower than those in the control group after treatment (P <0.05), abdominal pain, bloating, nausea and vomiting, Symptoms and other signs of disappearance of time were shorter than the control group (P <0.05). Conclusion: The effect of ulinastatin and somatostatin on elderly patients is significant, which can shorten the course of disease and inhibit the level of inflammatory cytokines. The curative effect is superior to that of routine treatment.