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近些年来,国内外学者对乙型肝炎肝细胞损伤的机理进行了大量研究。发现部分无症状 HBsAg 携带者肝内虽有病毒复制,但肝脏的组织形态和功能均无明显异常,说明病毒可能不直接引起肝脏损害。在乙型肝炎的病变组织内,坏死的肝细胞常和活化的单核炎症细胞紧密相连,因而认为机体的免疫应答可能是引起肝细胞损伤的重要原因,且宿主因素和病毒因素可导致机体免疫调节机能的紊乱,致使肝细胞持续损伤。本文就近些年国外有关乙型肝炎患者肝细胞损伤的免疫病理机制方面的文献作一综述。
In recent years, scholars at home and abroad have done a lot of research on the mechanism of hepatocellular injury in hepatitis B. Found that some asymptomatic HBsAg carriers in the liver despite viral replication, but the liver morphology and function were not abnormal, indicating that the virus may not directly cause liver damage. In diseased tissues of hepatitis B, necrotic hepatocytes are often closely linked to activated mononuclear inflammatory cells, and therefore the body’s immune response may be an important cause of hepatocellular injury, and host factors and viral factors can lead to immunity Regulate dysfunction, resulting in sustained damage to liver cells. This review summarizes the recent literature on the immunopathological mechanisms of hepatocellular injury in hepatitis B patients in foreign countries.