论文部分内容阅读
CT对比液可引起碘源性甲状腺机能亢进症(IIHT).作者综合报道了1987～1990年期间24600例CT扫描患者,7例因严重IIHT(甲状腺素222nmol/L,TSH 0.06mU/L)需住院治疗.患者是接受了含碘(3～12mg)CT对比液(如iohexol,甲泛影酸或Joxita-lamate)静脉注射后发病的.其量超过每日50μg生理需要量的60～240倍.放射性对比剂含有碘原子,可共价与酚环结合.这些成份不能被脱碘酶所代谢.沾染的游离碘存在于这些制剂之中,最高含量达20ug/ml(Nyconed Imag-ing.AS),可影响甲状腺功能.这些患者以前均未接触碘.并未发现甲状腺自身抗体,均发生多结节性
CT contrast fluid can cause iodine-derived hyperthyroidism (IIHT) .A comprehensive report from 1987 to 1990, 24,600 cases of CT scan patients, 7 patients with severe IIHT (thyroid hormone 222nmol / L, TSH 0.06mU / L) required Hospitalization Patients who have contracted intravenous injection of iodine (3 to 12 mg) CT contrast fluid (eg, iohexol, methamphetamine, or Joxita-lamate) in excess of 60 to 240 times the daily physiological requirement of 50 μg Radioactive contrast agents contain iodine atoms and are covalently bonded to the phenolic ring.These ingredients can not be metabolized by deiodinase.The contaminated free iodine is present in these formulations up to a maximum of 20 ug / ml (Nyconed Imag- ing.AS ), Can affect thyroid function in these patients have not been exposed to iodine before, did not find thyroid autoantibodies, occurred in multiple nodular