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目的探讨无水酒精局部注射肝肿瘤与肺转移的关系。方法将４７只大鼠分３组，酒精瘤内注射组（１６只）、盐水瘤内注射组（１５只）和对照组（１６只）。肝种植肿瘤后１０天，经腹按分组方法处理后２０分钟，切除肝肿瘤及其边缘５ｍｍ的肝组织，再饲养大鼠１０天剖杀。结果肝肿瘤标本组织学观察：酒精瘤内注射组和盐水瘤内注射组瘤组织块侵破肝静脉或肿瘤血管分别为３１％（５／１６）和２７％（４／１５），明显高于无此现象的对照组。３组肿瘤血管或肝静脉瘤栓检出率分别为７５％（１２／１６）、６７％（１０／１５）和２５％（４／１６），酒精瘤内注射组和盐水瘤内注射组显著高于对照组。肝肿瘤切除１０天后剖杀大鼠，３组肺转移结节数分别为３０±１４（１６例）、３３±１９（１５例）和１３±８（１１例），酒精瘤内注射组和盐水瘤内注射组明显高于对照组。结论无水酒精瘤内注射可促进肿瘤细胞侵入血管和肺转移，其原因与瘤内注射增加肿瘤内压力有关。
Objective To investigate the relationship between local injection of anhydrous ethanol and liver metastases. Methods 47 rats were divided into 3 groups, alcohol injection group (16), saline injection group (15) and control group (16). Ten days after implantation of the tumor in the liver, the liver tissue resected from the liver tumor and its margin of 5 mm was resected 20 minutes after the abdominal treatment according to the grouping method, and then the rats were sacrificed for 10 days. Results Histological observation of liver tumor specimens: 31% (5/16) and 27% (4/15) of invasive hepatic veins or tumor vessels were found in the group of intratumoral injection and intratumoral injection of tumor, respectively, which were significantly higher than Control group without this phenomenon. The detection rates of tumor vasculature or hepatic vein tumor thrombus in the three groups were 75% (12/16), 67% (10/15) and 25% (4/16), respectively. Higher than the control group. Rats were sacrificed 10 days after resection of the liver tumor. The number of pulmonary metastases in the three groups was 30 ± 14 (16 cases), 33 ± 19 (15 cases) and 13 ± 8 (11 cases), respectively. Intratumoral injection group was significantly higher than the control group. Conclusion Intratumoral injection of alcoholic alcohol can promote invasion of tumor cells into blood vessels and lung metastasis. The reason is related to the increase of intratumoral pressure in intratumoral injection.