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目的探讨C-反应蛋白(CRP)对慢性肾功能衰竭患者预后的影响。方法筛选安阳市人民医院肾内科2006年1月至2006年12月间住院慢性肾功能衰竭期、尿毒症期患者,入院后给予慢性肾功能衰竭标准治疗及对症治疗,第2天测定血浆高敏C-反应蛋白(hs-CRP)浓度。将入选者分为hs-CRP≤3 mg/L与hs-CRP>3 mg/L两组,分析两组3年再住院率及病死率。调整临床危险因素后,使用卡方检验评价CRP对慢性肾功能衰竭患者预后的影响。结果 112例入选者中67%hs-CRP>3 mg/L,其3年病死率高于hs-CRP≤3 mg/L组患者(P=0.03),3年再住院率两组间比较差异无统计学意义(P=0.24)。结论 CRP与慢性肾功能衰竭患者不良预后相关。
Objective To investigate the impact of C-reactive protein (CRP) on the prognosis of patients with chronic renal failure. Methods All patients with chronic renal failure and uremia admitted to Anyang People’s Hospital during January 2006 to December 2006 were treated with standard therapy and symptomatic treatment of chronic renal failure after admission. On the second day, plasma high-sensitivity C - Reactive protein (hs-CRP) concentration. The participants were divided into two groups: hs-CRP≤3 mg / L and hs-CRP> 3 mg / L. The 3-year rehospitalization rate and case fatality rate were analyzed. After adjustment for clinical risk factors, the impact of CRP on the prognosis of patients with chronic renal failure was assessed using the chi-square test. Results The 67% hs-CRP> 3 mg / L in 112 patients was higher than that in patients with hs-CRP≤3 mg / L (P = 0.03). The 3-year rehospitalization rate was significantly different between the two groups No statistical significance (P = 0.24). Conclusion CRP is associated with poor prognosis in patients with chronic renal failure.