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目的探讨syncytin在正常妊娠及子痫前期胎盘组织中的表达及意义。方法采用荧光实时定量PCR(Real-time FQ-PCR)方法检测正常晚期妊娠(20例)、晚发型子痫前期轻度(20例)、重度(25例)及早发型重度子痫前期(15例)胎盘组织中syncytin mRNA表达。结果 Syncytin mRNA在正常妊娠晚期及子痫前期胎盘组织中均有表达;晚发型子痫前期与正常晚孕比较,胎盘组织syncytin mRNA表达降低,且与病情严重程度相关;早发型与晚发型比较,早发型重度子痫前期表达降低更为明显,差异有统计学意义(P<0.01)。结论 Syncytin mRNA在子痫前期胎盘组织中表达降低,早发型降低更为明显,而syncytin与滋养细胞融合有关,提示滋养细胞融合障碍可能在子痫前期发病中发挥作用。
Objective To investigate the expression and significance of syncytin in normal pregnancy and preeclampsia placenta. Methods Real-time FQ-PCR was used to detect normal late pregnant women (20 cases), late onset preeclampsia (20 cases), severe cases (25 cases) and early-onset severe preeclampsia (15 cases Syncytin mRNA expression in placental tissue. Results Syncytin mRNA was expressed in both normal and preeclampsia placenta. The expression of syncytin mRNA in placenta was lower in late onset preeclampsia compared with that in normal pregnancy, which was correlated with the severity of the disease. Compared with late onset, Premature onset severe preeclampsia expression decreased more significantly, the difference was statistically significant (P <0.01). Conclusions The expression of Syncytin mRNA in placenta of preeclampsia is lower than that in preeclampsia. The decrease of early hair loss is more obvious. Syncytin is associated with the trophoblast fusion, suggesting that the disorder of trophoblast fusion may play a role in the pathogenesis of preeclampsia.