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目的：探讨谷胱甘肽辅助治疗重型病毒性肝炎和肝炎肝硬化的疗效。方法：４０例病人分成２组，治疗组２０例（男性１６例，女性４例；年龄４４±ｓ１１ａ）在综合性治疗（用甘草酸二铵、肝细胞生长因子、茵栀黄等）基础上用谷胱甘肽０．６～１．２ｇ加入１０％葡萄糖注射液２５０ｍＬ中静脉滴注，ｑｄ，连续１～２ｍｏ。对照组２０例（男性１８例，女性２例；年龄４６±１２ａ）单用综合治疗。结果：治疗组症状、体征改善明显优于对照组（Ｐ＜０．０１，Ｐ＜０．０５）。总胆红素、凝血酶原时间变化亦优于对照组（Ｐ＜０．０５），但丙氨酸转氨酶治疗后２组间无明显差别（Ｐ＞０．０５）。结论：谷胱甘肽辅助治疗病毒性肝炎及肝炎肝硬化有较好的疗效。
Objective: To investigate the therapeutic effect of glutathione in the treatment of severe viral hepatitis and hepatitis cirrhosis. Methods: Forty patients were divided into two groups: 20 in treatment group (16 males and 4 females; age 44 ± s11a). On the basis of comprehensive treatment (diammonium glycyrrhizinate, hepatocyte growth factor, Yin Zhihuang etc.) Glutathione 0.6 ~ 1.2g by adding 10% glucose injection 250mL intravenous infusion, qd, continuous 1 ~ 2mo. Control group of 20 patients (18 males, 2 females; age 46 ± 12a) combined treatment alone. Results: The symptoms and signs of treatment group were significantly better than those of control group (P <0.01, P <0.05). Total bilirubin and prothrombin time was also better than the control group (P <0.05), but there was no significant difference between the two groups after alanine aminotransferase treatment (P> 0.05). Conclusion: Glutathione adjuvant treatment of viral hepatitis and hepatitis cirrhosis have a good effect.