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钙EDTA所致的尿中排铅量,根据给药方法(特别是给药速度)将有何种变化,对12名铅作业工人(22～66)岁男子,血中铅10～60微克/100克进行了探讨研究。 (1)6名铅作业工人饮用水500毫升后,立即快速静脉注射钙EDTA20毫克/公斤体重,从静注开始,分别于1、2、4、8、12及到24小时后,测定尿铅排出量。尿铅排出量从1～2小时后达到顶峰后逐渐减少。由静注开始4小时后可见到24小时铅排出量的50％。 (2)对9名铅作业工人将钙EDTA20毫克/公斤体重溶于5％葡萄糖250毫升,以不到1小时速度静脉滴注完毕。同样从静脲点滴开始到24小时后测定尿中铅排出量(平均0.55毫克/24小时)。平均每单位时间尿铅量从静脉点滴开始1～2小时后出现最高值,自点滴后5小时可看到50％值。 (3)对8名铅作业工人,将钙EDTA40～60
According to the method of administration (especially the speed of administration), the amount of lead excretion in calcium-induced urinary excretion of lead in the blood of 12 lead workers (aged 22-66), blood lead levels of 10-60 μg / 100 grams were studied. (1) Immediately after intravenous infusion of 500 ml of drinking water from 6 lead workers, 20 mg / kg of calcium EDTA was administered to patients starting from 1, 2, 4, 8, 12 and 24 hours after the start of intravenous Emissions. Excretion of lead in urine from 1 to 2 hours after peaked gradually reduced. 4 hours after the beginning of intravenous infusion can be seen 24 hours of lead discharge of 50%. (2) Nine lead workers dissolve calcium EDTA 20 mg / kg body weight in 250 ml of 5% dextrose to complete intravenous infusion in less than 1 hour. The urinary lead excretion was also measured 24 hours after intravenous infusion of urea (0.55 mg / 24 hours on average). The average amount of urinary lead per unit time from the intravenous drip started 1 to 2 hours after the highest value, 5 hours after the drip can be seen 50% value. (3) 8 lead workers, the calcium EDTA40 ~ 60