【摘 要】
:
Proteasome activity reduction is all important pathological phenomenon,resulting in proteins aggregation and neuronal death in the injured neurons induced by tr
【机 构】
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Department of Neurosurgery,Department of Hand Surgery,Department of Histoembryology,Department of Ga
【基金项目】
:
国家自然科学基金;the International Cooperation Grant;the Outstanding Youth Grant from the Science and Technology Department of Jilin Province,China
论文部分内容阅读
Proteasome activity reduction is all important pathological phenomenon,resulting in proteins aggregation and neuronal death in the injured neurons induced by transient ischemia.Our previous report showed that the trap of proteasome in the protein aggregates WaS a reason to lead to the reduction of proteasome activity.However, the patterns of proteasome entered into protein aggregates are not clear.In this study,we used a global ischemia model,Hematoxylin-Eosin staining,differential centrifuge,proteasome activity assay,sucrose gradient density centrifuge,and Western blot analysis to investigate this problem.Our results show that there are two aggregation pattems of proteasome after transient ischemia and reperfusion.One is that 26S proteasome is trapped by protein aggregates as a whole unit,and the other is that 19S or 20S is trapped in the protein aggregates,respectively,after 26S disassociates.
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