用束缚+浸水应激模型,观察了侧脑室内注射去甲肾上腺素(NE)对大鼠应激性胃溃疡的影响,并对其作用机制进行了初步的探讨。结果为:侧脑室内注射NE后,能明显减轻大鼠应激性胃溃疡,并似有剂量一效应依赖关系;脑室内和皮下注射酚妥拉明及心得安后,能阻断NE的效应;室旁核内分别注射NE及心得安,能各自减轻和加强应激性胃溃疡的发生。这些结果表明,脑内NE可能通过室旁核的作用,参与了对应激性胃溃疡的调节。 The effects of intracerebroventricular injection of norepinephrine (NE) on stress gastric ulcer in rats were observed by using binding + water immersion stress model. The mechanism of action was also discussed. The results showed that intracerebroventricular injection of NE could significantly relieve stress gastric ulcer in rats and appeared to be dose-dependently dependent. Intraventricular and subcutaneous injection of phentolamine and propranolol blocked the effect of NE ; Paraventricular nucleus were injected NE and propranolol, respectively, can reduce and strengthen the occurrence of stress ulcer. These results suggest that intracerebral NE may be involved in the regulation of stress ulcer through the paraventricular nucleus.