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通过对黄曲霉毒素摄入、乙型肝炎感染、饮用污染塘水三因素的流行病学调查分析,结果表明三因素有协同致肝癌作用.根据8353例肝癌高发人群(男性,30～59岁)的HBsAg携带者(RIA法)的三年前瞻性观察,HBsAg(+)组的肝癌发病率高达1260.66/10万,HBsAg(-)组仅28.62/10万,CRR为44.04,标化相对危险性(SRR)为45.91.结合黄曲霉毒素摄入量共同分析,RR随着HBsAg携带情况和玉米食用量(代替AFB_1摄入情况)的增加呈梯度上升.根据两因素特异发病率和特异危险的分析,该两因素呈相乘的协同作用.
Through the epidemiological investigation of the three factors of aflatoxin intake, hepatitis B infection, and drinking polluted pond water, the results showed that three factors have a synergistic effect on liver cancer. According to 8353 cases of high incidence of liver cancer (male, 30 to 59 years old) A three-year prospective observation of HBsAg carriers (RIA) showed that the incidence of liver cancer in the HBsAg(+) group was as high as 1,126.66/100,000, and that of the HBsAg(-) group was only 28.62/100,000, and the CRR was 44.04. (SRR) was 45.91. Combined with the analysis of aflatoxin intake, RR increased gradually with the increase of HBsAg carrier and corn consumption (instead of AFB_1 intake). According to the analysis of two factors specific morbidity and specific risk The two factors are synergistically multiplied.