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随着聚合酶链反应 (ＰＣＲ)及其扩增产物直接测序等分子生物学技术的发展和应用 ,使人们从分子水平认识病毒及其变异成为可能。机体在感染乙肝病毒 (ＨＢＶ)后能够产生活跃的抗病毒细胞免疫反应 ,然而仍有许多ＨＢＶ感染者不能清除病毒 ,成为持续病毒携带者。引起持续性ＨＢＶ
With the development and application of molecular biology techniques such as polymerase chain reaction (PCR) and its direct sequencing of amplified products, it is possible to recognize the virus and its variation at the molecular level. The body produces an active antiviral cellular immune response after infection with hepatitis B virus. However, many HBV carriers still can not clear the virus and become persistent virus carriers. Cause persistent HBV