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目的:研究云芝提取液对小鼠移植性动物实体肿瘤的抑制作用。方法:按常规方法接种肿瘤24小时后,云芝口服液在20~60g干药·kg-1/d剂量范围内,连续灌胃7天,计算其抑瘤率。结果:小鼠S-180的抑瘤率为31.3~51.8%之间,均P<0.001,对小鼠肝癌的抑制率为46.2~66.5%之间,均P<0.001;对小鼠L-Ⅱ的抑制率为37.9~64.6%之间,均P<0.001。各组试验小鼠用药后体重有明显增加,其增加幅度与阴性对照相比基本无差异,各组用药小鼠在实验中一般状态良好。结论:抑瘤试验表明,对小鼠S-180、小鼠肝癌和小鼠L-Ⅱ均有明显的抑制作用,未见有毒副作用。
Objective: To study the inhibitory effect of Yunzhi extract on the solid tumor in mice transplanted animals. Methods: 24 hours after the tumor was inoculated according to the routine method, Yunzhi oral solution was administrated continuously for 7 days in the dosage of 20-60g dry drug · kg-1 / d, and the tumor inhibition rate was calculated. Results: The inhibitory rate of S-180 in mice was 31.3-51.8%, both P <0.001, and the inhibitory rate of mouse S-180 was 46.2-66.5% P <0.001; the inhibitory rate of L-Ⅱ in mice was 37.9-64.6%, both P <0.001. The weight of mice in each test group increased significantly after treatment, and the increase range was basically no difference compared with the negative control group. The mice in each group were generally good in the experiment. Conclusion: The anti-tumor test showed that the inhibitory effect was obvious on mouse S-180, mouse liver cancer and mouse L-Ⅱ, no toxic side effects.