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目的:评价0.1%他克莫司治疗糜烂型口腔扁平苔癣(OLP)的疗效和安全性。方法:根据相关标准纳入68例糜烂型OLP患者,随机分成两组,双盲法下分别外用0.1%他克莫司和0.05%丙酸氯倍他索治疗,观察和比较两组的总有效率、不良反应发生率及停药6个月后复发率。结果:他克莫司组和丙酸氯倍他索组总有效率分别为97.1%、93.9%,两组间差异无统计学意义(P>0.05);两组间复发率分别为6.5%、10.3%,差异无统计学意义(P>0.05);两组的局部不良反应发生率均较低且无显著差异(P>0.05)。结论:局部外用他克莫司在改善OLP患者体征(病损面积)和症状(疼痛)方面效果显著;他克莫司治疗OLP的总有效率、治疗期间局部不良反应发生率及停药后复发率均与糖皮质激素相当。
Objective: To evaluate the efficacy and safety of 0.1% tacrolimus in the treatment of erosive oral lichen planus (OLP). Methods: According to the relevant standards, 68 patients with erosive OLP were enrolled and randomly divided into two groups. The patients were treated with 0.1% tacrolimus and 0.05% clobetasol propionate respectively under the double-blind method. The total effective rate , The incidence of adverse reactions and relapse rate after 6 months withdrawal. Results: The total effective rates of tacrolimus group and clobetasol propionate group were 97.1% and 93.9%, respectively. There was no significant difference between the two groups (P> 0.05). The recurrence rates were 6.5% 10.3%, the difference was not statistically significant (P> 0.05). The incidence of local adverse reactions in both groups was lower and no significant difference (P> 0.05). CONCLUSIONS: Topical topical tacrolimus is effective in improving signs (area of lesions) and symptoms (pain) in OLP patients; the overall effective rate of OLP with tacrolimus, the incidence of local adverse reactions during treatment, and recurrence after discontinuation Rate and glucocorticoid are quite.