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目的总结乳腺癌干细胞与基因分型的研究进展,并分析二者之间的相关性。方法分析近年来有关乳腺癌干细胞与基因分型研究的文献报道。结果乳腺癌干细胞与基因分型的相关性研究支持了乳腺癌的肿瘤干细胞起源学说,解释了乳腺癌基因分型的复杂性及其异质性。结论乳腺癌干细胞和基因分型的相关性研究能为从细胞分子水平研究乳腺癌的形成机理和生物学特性找到新的途径,有望为乳腺癌的诊断和治疗提供新的策略与手段。
Objective To summarize the research progress of breast cancer stem cells and genotyping and to analyze the correlation between the two. Methods In recent years, reports on breast cancer stem cells and genotyping were reported. Results The correlation between breast cancer stem cells and genotyping supported the theory of stem cell stem cell origin in breast cancer and explained the complexity and heterogeneity of breast cancer genotyping. Conclusion The correlation between breast cancer stem cells and genotyping can find a new way to study the formation mechanism and biological characteristics of breast cancer at the cellular and molecular level. It is expected to provide a new strategy and method for the diagnosis and treatment of breast cancer.