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基质金属蛋白酶及其组织抑制物(MMPs/TIMPs)主要调节细胞外基质(ECM)成分的沉积和降解,广泛分布于子宫内膜,表达具有时间性和空间性,与子宫内膜的周期性增生和剥脱相一致,参与月经发生、内膜重塑、内膜血管修复。其表达受雌、孕激素及局部细胞因子的影响。子宫内膜局部不适当的几种MMPs的激活和表达及TIMPs的相对或绝对下降导致MMPs/TIMPs平衡改变,触发了子宫内膜不规则出血。
Matrix metalloproteinases and their tissue inhibitors (MMPs / TIMPs) mainly regulate the deposition and degradation of extracellular matrix (ECM) components, widely distributed in the endometrium, the expression of time and space, and the endometrial cyclical hyperplasia Consistent with exfoliation, involved in menstruation, endometrial remodeling, endovascular repair. Its expression by the estrogen, progesterone and local cytokines. Activation and expression of several MMPs that are inappropriately localized in the endometrium and a relative or absolute decrease in TIMPs lead to a balanced change in MMPs / TIMPs that triggers irregular endometrial bleeding.