心钠素(简称ANF),最初是在哺乳动物心房内发现的一种生物活性多肽。它作为一种循环激素在水盐代谢、心血管活动调节中有重要作用。近年来,又发现在心室、肺、下丘脑及垂体等多处也有心钠素样免疫活性物质。大量研究表明,心钠素在高血压病发病中有重要意义,如自发性高血压大鼠血浆和心房心钠素含量明显升高,且心房心钠素基因的转录活性也显著提高。为进一步证明心室和肺组织也能自身合成 Atrial natriuretic factor (ANF), originally a bioactive peptide found in mammalian atria. It acts as a circulating hormone in water and salt metabolism, cardiovascular regulation has an important role. In recent years, they also found in the ventricular, pulmonary, hypothalamus and pituitary and other places also have atrial natriuretic-like immunocompetent substances. A large number of studies have shown that atrial natriuretic peptide in the pathogenesis of hypertension is of great significance, such as spontaneously hypertensive rats plasma and atrial natriuretic peptide was significantly increased, and atrial natriuretic peptide gene transcriptional activity was also significantly increased. To further prove that ventricular and lung tissue can also be their own synthesis