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盐酸克林霉素为林可霉素的衍生物,抗菌谱和林可霉素相同,抗菌作用为后者4~8倍,临床主要适用于链球菌属、葡萄球菌属及厌氧菌(包括脆弱拟杆菌、产气荚膜杆菌、放线菌等)所致的中、重度感染,如吸入性肺炎、脓胸、肺脓肿、骨髓炎、腹腔感染、盆腔感染及败血症等。临床应用及文献报道中的常见不良反应以皮肤损害、消化系统损害和全身症状为主[1];严重不良反应以伪膜性肠炎、过敏性休克[2]、肾功能损害[5]为主,
Clindamycin hydrochloride is a derivative of lincomycin. The antibacterial spectrum is the same as that of lincomycin. The antibacterial activity is 4 to 8 times that of the latter. The clinical application is mainly applicable to Streptococcus, Staphylococcus and anaerobic bacteria Bacteroides fragilis, Clostridium perfringens, Actinomyces, etc.) caused by moderate and severe infections, such as aspiration pneumonia, empyema, lung abscess, osteomyelitis, abdominal infection, pelvic infection and sepsis. Common clinical and literature reports of adverse reactions to skin damage, digestive system damage and systemic symptoms [1]; serious adverse reactions to pseudomembranous colitis, anaphylactic shock [2], renal damage [5] based ,