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为了探讨中度高原低氧环境对健康老年人肾功能的影响,我们对63例健康老年人和17例肺心病患者进行了血肌酐,血、尿β_2—微球旦白,血流变学检测。结果示:50～60岁和60岁以上健康老年人肌酐清除率分别为1.64±0.20 1.39±0.29ml·s~(-1)/1.73m~2老年组与中年组相比平均下降21.03％,按平均年龄比较每年递减1.701％,缺氧(PaO_25.76±1.03kPa)和二氧化碳正常的肺心病患者肌酐清除率明显低于50岁组(P<0.01)。Ccr平均每年递减4.614％,与年龄相同的老年对照组相比,Ccr平均下降32.66％。血β_2—微球旦白与Ccr成负相关,结果表明:中度高原低氧环境健康中年人肾小球滤过率可保持正常范围,健康老年人肾功能有轻微损伤,肺心病患者肾功能损伤尤为严重,作者认为,在一定条件下,肾功能损伤不仅与缺氧的直接作用有关,而且与血液流变学改变而致肾血流量改变有关。
In order to investigate the effect of hypoxia on the renal function in healthy elderly, we measured the serum creatinine, blood and urine β 2 -microglobulin, hemorheology in 63 healthy elderly and 17 patients with pulmonary heart disease . The results showed that: creatinine clearance rate of healthy elderly people aged 50 ~ 60 and over 60 were 1.64 ± 0.20 1.39 ± 0.29ml · s -1 /1.73m ~ 2, respectively, and the average age of old people was 21.03% (1.701%) decreased by average age. The creatinine clearance rate of patients with cor pulmonale with hypoxia (PaO_25.76 ± 1.03kPa) and normal carbon dioxide was significantly lower than that of the 50s (P <0.01). Ccr decreased by an average of 4.614% per year, compared with the same age-old control group, Ccr decreased by an average of 32.66%. Blood β 2 -microglobulin and Ccr negatively correlated, the results showed that: moderate high altitude hypoxic environment in healthy middle-aged glomerular filtration rate can maintain the normal range of healthy elderly with mild renal damage, pulmonary heart disease in patients with kidney Functional damage is particularly serious, the author believes that under certain conditions, renal injury is not only related to the direct effect of hypoxia, but also with changes in blood flow caused by changes in renal blood flow.