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目的:研究肾移植术后环孢素(CsA)血药浓度与患者体内因素的相关性。方法:采用回顾性调查方法,查阅我院肾移植术后1周～1个月内服用CsA的患者病历,记录CsA血药浓度及相应的生化检验值,并应用SPSS13.0统计软件对数据进行全回归分析和多元线性回归分析。结果:全回归分析表明,在丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、AST/ALT、总蛋白(TP)、白蛋白(ALB)、直接胆红素(DBIL)、间接胆红素(IBIL)、胆碱酯酶(CHE)、总胆汁酸(TBA)、乳酸脱氢酶(LDH)、尿素(Urea)、尿酸(UA)、肌酐(Crea)等生化因素协同存在的情况下,上述各值与CsA单位剂量血药浓度存在线性关系(P<0.05);进一步用多元线性回归分析表明,CsA单位剂量血药浓度与TP之间存在线性关系(P<0.05)。结论:患者TP是影响CsA血药浓度的独立因素。而ALT、AST、AST/ALT、ALB、DBIL、IBIL、CHE、TBA、LDH、Urea、UA、Crea等可能与TP协同作用而影响CsA血药浓度。
Objective: To study the correlation between CsA concentration in plasma and patient’s in vivo after renal transplantation. Methods: We retrospectively investigated the medical records of patients taking CsA within 1 week to 1 month after renal transplantation in our hospital, and recorded the blood concentration of CsA and corresponding biochemical test values, and applied SPSS13.0 statistical software to conduct data analysis Full regression analysis and multiple linear regression analysis. Results: A total regression analysis showed that there was no significant difference in ALT, AST, AST / ALT, total protein (TP), albumin (ALB), direct bilirubin ), IBIL, CHE, TBA, LDH, Urea, UA, Crea and other biochemical factors There was a linear relationship between the above values and the unit dose of CsA (P <0.05). The multiple linear regression analysis showed that there was a linear relationship between unit dose of CsA and TP (P <0.05 ). Conclusion: Patient TP is an independent factor affecting the plasma concentration of CsA. ALT, AST, AST / ALT, ALB, DBIL, IBIL, CHE, TBA, LDH, Urea, UA and Crea may affect the serum concentration of CsA in combination with TP.