论文部分内容阅读
目的 探讨层粘连蛋白(LN)的表达与胃癌分化、浸润和转移的关系。方法 采用免疫组化S-P法检测51例胃癌组织中LN的表达情况。结果 LN在胃癌组织中的阳性率为41.2％(21/51),呈连续线状型、间断线状型、碎片状型及完全缺失型4种方式分布。LN表达的类型与胃癌的分化程度、浸润深度及淋巴结转移均有明显关系。结论 LN的减少或消失,可能是胃癌浸润转移的机制之一。
Objective To investigate the relationship between laminin (LN) expression and differentiation, invasion and metastasis of gastric cancer. Methods Immunohistochemical S-P method was used to detect the expression of LN in 51 cases of gastric cancer. Results The positive rate of LN in gastric cancer tissues was 41.2% (21/51). The distribution of LN was continuous linear, intermittent linear, fragmentary and complete deletion. The type of LN expression was significantly related to the degree of differentiation of gastric cancer, depth of invasion, and lymph node metastasis. Conclusion The decrease or disappearance of LN may be one of the mechanisms of gastric cancer invasion and metastasis.