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采用荧光分光光度法、亚硝酸盐形成法和硫代巴比妥酸法测定肺癌患者（肺癌组）和肺部良性疾病患者（良性组）培养血淋巴细胞芳香烃羟化酶（ＡＨＨ）诱导性和血清超氧化物歧化酶（ＳＯＤ）活性及脂质过氧化物（ＬＰＯ）水平。结果显示：肺癌组ＡＨＨ诱导性比健康组和良性组显著增加（Ｐ＜００１），其高、中诱导性为５５１７％、３４４８％；血清ＳＯＤ活性肺癌组比健康组和肺部良性疾患组显著下降（Ｐ＜００５）；ＬＰＯ水平随病变进展明显升高，组间有显著性差异（Ｐ＜００１）。ＬＰＯ／ＳＯＤ值随病变进展显著升高（Ｐ＜００１）。肺癌组ＳＯＤ活性下降，ＬＰＯ水平升高，呈显著负相关（Ｐ＜００５）。提示：人血淋巴细胞ＡＨＨ诱导性、血清ＳＯＤ活性及ＬＰＯ水平与疾病发生和发展之间可能存在一定的关系。肺癌的易感性可能与ＡＨＨ高诱导性、ＳＯＤ活性下降及ＬＰＯ水平显著升高有关。检测上述指标将有助于肺癌的诊断、肺癌易感者的筛选。
The induction of aromatase hydroxylase (AHH) in cultured lymphocytes of lung cancer patients (lung cancer group) and patients with benign lung disease (benign group) by fluorescence spectrophotometry, nitrite formation and thiobarbituric acid method And serum superoxide dismutase (SOD) activity and lipid peroxide (LPO) levels. The results showed that the induction rate of AHH in lung cancer group was significantly higher than that in healthy group and benign group (P <001), and the high and intermediate inducibility was 5517% and 3448% respectively. Serum SOD activity in lung cancer group was higher than that in healthy group and Lung benign disease group decreased significantly (P <0 05); LPO levels increased significantly with the progression of the disease, there was a significant difference between groups (P <0 01). The LPO / SOD value increased significantly with the progression of the disease (P <001). The activity of SOD in lung cancer group decreased and the level of LPO increased in a negative correlation (P <005). Tip: AHH induced human blood lymphocytes, serum SOD activity and LPO levels may have a certain relationship between the occurrence and development of the disease. The susceptibility of lung cancer may be related to the high induction of AHH, the decrease of SOD activity and the significant increase of LPO level. Detection of these indicators will help the diagnosis of lung cancer, lung cancer susceptibility screening.