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目的:探讨非小细胞肺癌(NSCLC)组织中血管浸润(BVI)和淋巴管浸润(LVI)所发生的不同程度的表达及其与NSCLC生物学行为的关系。方法:常规HE切片在光镜下从低倍镜到高倍镜全面观察切片,对116例NSCLC标本的BVI和LVI表达情况进行研究,分析其与临床病理因素的关系及内在联系。结果:NSCLC组BVI和LVI的阳性表达率分别为44.8%和31.9%,血管浸润和淋巴管浸润与NSCLC患者病理类型、肿瘤细胞分化程度、肿瘤大小以及患者年龄、性别无关;各术后TNM分期的BVI发生比较:Ⅰ期与Ⅲ期相比有显著性差异(P<0.05);各术后TNM分期的LVI发生比较:Ⅰ期∶Ⅱ期、Ⅰ期∶Ⅲ期LVI的发生相比有显著性差异(P<0.05);各N分期的BVI比较:0组∶1～3组、0组∶2组BVI的发生有显著性差异(P<0.05);各N分期的LVI比较:0组∶1～3组、0组∶2组LVI的发生有显著性差异(P<0.05)。结论:血管浸润、淋巴管浸润与淋巴结转移及术后TNM的高分期密切相关,对NSCLC临床病理学评价有重要意义。
Objective: To investigate the differential expression of vascular infiltration (BVI) and lymphatic invasion (LVI) in non-small cell lung cancer (NSCLC) and its relationship with the biological behavior of NSCLC. Methods: The sections of conventional HE sections were observed under low light and high power at light microscope. The expressions of BVI and LVI in 116 NSCLC specimens were studied. The relationship between them and clinicopathological factors was analyzed. Results: The positive rates of BVI and LVI in NSCLC group were 44.8% and 31.9% respectively. The infiltration of vascular and lymphatic invasion was not related to the pathological type, tumor cell differentiation, tumor size and age and sex in patients with NSCLC. The postoperative TNM stage (P <0.05). There was significant difference in the incidence of BMI between stage I and stage III (P <0.05). Stage I: stage II, stage I: stage III LVI was significantly different (P <0.05). The comparison of BVI in each N stage: Group 0: Group 1 ~ 3, Group 0: The incidence of BVI in group 2 was significantly different (P <0.05) There were significant differences in the incidence of LVI between groups 1 and 3 and group 0 and group 2 (P <0.05). Conclusion: The relationship between vascular infiltration, lymphatic invasion and lymph node metastasis and postoperative TNM stage is closely related to the clinicopathological evaluation of NSCLC.