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目的:分析研究急性有机磷农药中毒造成呼吸衰竭的相关原因。方法:抽取近年来在我院收治的患有急性有机磷农药中毒的病人80例,其中包括呼吸衰竭和非呼吸衰竭,呼吸衰竭病人为实验组,非呼吸衰竭病人为对照组,对呼吸衰竭出现时间、因素以及原因进行密切观察,同时对病人的血糖、脏器损伤情况、洗胃以及住院当中阿托品使用量进行对比分析。结果:急性有机磷农药中毒造成呼吸衰竭的因素包括有呼吸中枢衰竭、肺水肿以及解毒剂等使用过量,实验组APACHEⅡ评分、脏器损伤数量以及使用阿托品总体剂量显著大于对照组(P<0.05);实验组胆碱酯酶要比对照组低(P<0.05);实验组留置胃管间断洗胃例数显著低于对照组(P<0.05)。结论:对急性有机磷农药中毒伴有呼吸衰竭可以通过胆碱酯酶以及APACHEⅡ进行预测。对呼吸衰竭采用留置胃管进行洗胃可以取得明显的预防和治疗效果,同时采取合理、有效的阿托品对预防和治疗呼吸衰竭起到非常关键的作用,具有临床推广价值。
Objective: To analyze the related causes of respiratory failure caused by acute organophosphorus pesticide poisoning. Methods: Eighty patients with acute organophosphorus pesticide poisoning admitted to our hospital in recent years were enrolled, including respiratory failure and non-respiratory failure, patients with respiratory failure as experimental group and non-respiratory failure patients as control group. Respiratory failure occurred Time, factors and the reasons for the close observation, at the same time on the patient’s blood glucose, organ damage, gastric lavage and hospital use of atropine comparative analysis. Results: Acute organophosphorus pesticide poisoning caused respiratory failure factors include respiratory failure, pulmonary edema and excessive use of antidote, APACHE Ⅱ score in experimental group, the number of organ damage and the overall dose of atropine was significantly greater than the control group (P <0.05) ; The cholinesterase in experimental group was lower than that in control group (P <0.05). The number of gastric lavage gastric lavage in experimental group was significantly lower than that in control group (P <0.05). Conclusion: Acute organophosphorus pesticide poisoning with respiratory failure can be predicted by cholinesterase and APACHE Ⅱ. Gastric lavage using gastric lavage for respiratory failure can achieve significant preventive and curative effects. At the same time, taking a reasonable and effective atropine plays a key role in the prevention and treatment of respiratory failure and has clinical promotion value.