神经母细胞瘤(NB)是儿童时期常见的恶性肿瘤之一。发病隐匿,致使70%的病例在临床被发现时已为时过晚,丧失治疗良机。因此,对 NB 的早期发现颇为关键。NB 和正常交感神经细胞一样,摄取血中酪氨酸并生成儿茶酚胺(CA)。CA 最终代谢产物—香草扁桃酸(VMA)、高香草酸(HVA)、香草乳酸(VLA)均排泄于尿中。在正常人尿中含量极少,而在 NB 病人尿中明显升高。双向纸层析法可检测病人尿中三种代谢产物的存在,对 NB 的早期诊断具有重要意义。 Neuroblastoma (NB) is one of the most common malignancies in childhood. Hidden occurence, resulting in 70% of cases in the clinical was found too late, the loss of treatment opportunity. Therefore, the early detection of NB is quite crucial. Like normal sympathetic nerve cells, NB takes up blood tyrosine and produces catecholamines (CA). The final metabolite of CA - VMA, HVA and VLA were all excreted in the urine. In normal urine content is very small, but significantly increased urinary NB patients. Bidirectional paper chromatography can detect the presence of three metabolites in the urine of patients with early diagnosis of NB is of great significance.