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目的:研究血清瘦素水平与脂肪肝发病之间的关系。方法:选择脂肪肝患者28例,正常对照组30例,分别测量受试者的身高、体重,计算体重指数(BMI),血清瘦素水平用酶联免疫吸附实验方法(ELISA)测定,同时检测所有授试者的血清空腹血糖(FPG),空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR)。结果:脂肪肝患者的血清LP,FPG,FINS水平及BME HOMA-IR值明显高与正常对照组,差异有显著性。结论:血清LP水平及与其有密切关系的相关指标与脂肪肝的发病有直接的联系。
Objective: To study the relationship between serum leptin level and fatty liver disease. Methods: Twenty-eight patients with fatty liver and 30 normal controls were enrolled in this study. The height, weight, body mass index (BMI) and serum leptin level were measured by enzyme-linked immunosorbent assay (ELISA) Serum fasting plasma glucose (FPG), fasting insulin (FINS), and insulin resistance index (HOMA-IR) were calculated for all participants. Results: The levels of serum LP, FPG, FINS and BME HOMA-IR in patients with fatty liver were significantly higher than those in normal controls, the difference was significant. Conclusion: There is a direct relationship between the level of serum LP and related indicators closely related to the pathogenesis of fatty liver.