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近年来的研究表明,白介素-1(interleukin-1,IL-1)在机体的抗肿瘤反应中起十分重要的作用,它具有免疫正向调节和直接杀瘤效应,但是在胃癌患者中是否存在IL-1低下尚未见报道。为了探讨IL-1与胃癌发病的关系,我们检测了胃癌(GC)及癌前病变即慢性胃溃疡(CGU)患者血清、组织培养上清中的IL-1水平并探讨了其临床意义。 1 材料和方法 1.1 材料 ①胃癌及胃溃疡:随机选择门诊或住院GC 27例,男20例,女7例,年龄36岁～72岁,平均年龄58.4岁±9.6岁;CGU 25例,男14例,女11例,年龄17岁～73岁,平均年龄51.8岁±14.1岁。以上病例均由内镜和病理证实。②正常对照组(n)共22例,男13例,女9例,年龄16岁～61岁,平均年
Recent studies have shown that interleukin-1 (IL-1) plays an important role in the body’s anti-tumor response. It has positive immunomodulation and direct tumoricidal effect, but it exists in patients with gastric cancer. The low IL-1 level has not been reported. In order to explore the relationship between IL-1 and the pathogenesis of gastric cancer, we examined the levels of IL-1 in serum and tissue culture supernatants of patients with gastric cancer (GC) and precancerous lesions, ie, chronic gastric ulcers (CGU), and explored their clinical significance. 1 Materials and Methods 1.1 Materials 1 Gastric and gastric ulcers: 27 outpatients were randomly selected from the outpatient or hospitalized GC, 20 males and 7 females, aged 36 to 72 years, mean age 58.4 years ± 9.6 years; CGU 25 patients, male 14 Cases, 11 women, aged 17 to 73 years, mean age 51.8 years ± 14.1 years old. The above cases were confirmed by endoscopy and pathology. 2 Normal control group (n) 22 cases in total, 13 males and 9 females, aged 16 to 61 years, average years