Danlou Fang(丹蒌方)reduces microvascular obstruction through the endothelial/inducible nitric oxide syn

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OBJECTIVE:To investigate the efficacy of the Dan-lou Fang(DL)Traditional Chinese Medicine formula on microvascular obstruction(no-reflow)through the endothelial/inducible nitric oxide synthase(eNOS/iNOS)pathway in a rat model.METHODS:Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion(or sham proce-dure)followed by 2 h of reperfusion and were then divided into treatment groups:sham,model,DL(500 mg/kg),DL(500 mg/kg)+eNOS inhibitor L-ni-troarginine(L-NNA;7.5 mg/kg),and sodium nitro-prusside(SNP;0.5 mg/kg).There were 16 per group.Areas of no-reflow were determined by thio-flavin S staining of heart tissue.Cardiac function was assessed by echocardiography.Myocardial en-zymes and antioxidants in serum were measured and analyzed.The relative protein expression levels of eNOS and iNOS were determined by western blotting.RESULTS:DL had a myocardial protective effect on myocardial reperfusion and reduced the area of no-reflow.The serum levels of creatine kinase(CK),myocardial CK isoenzyme CK-MB,and lactate dehy-drogenase were significantly lower in the DL group than in the model(P<0.05).DL treatment also de-creased the serum content of malondialdehyde and reactive oxygen species(ROS),increased the activity of superoxide dismutase and nitric oxide,and promoted eNOS expression(P<0.05)while lowering iNOS expression.CONCLUSION:DL reduced the area of no-reflow and had a myocardial protective effect that may be associated with the eNOS/iNOS pathway.
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