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目的分析儿童嗜酸粒细胞性胃肠炎的临床诊治。方法选取2013年2月~2015年6月本院消化儿科确诊为儿童嗜酸粒细胞性胃肠炎患者56例,全面准确记录患儿的临床表现、实验室检查结果、血清学指标、便常规表现及药物治疗情况。结果儿童嗜酸粒细胞性胃肠炎患者的临床症状主要以腹痛为主,主要并发症为贫血。同时对56例进行胃肠镜检查,胃镜下可见胃肠黏膜红斑、黏膜颗粒样改变、糜烂、出血、溃疡形成等非特异性改变,以黏膜颗粒样改变居多,所有儿童嗜酸粒细胞性胃肠炎患者均给予抗幽门螺杆菌治疗,同时口服孟鲁司特钠配合治疗,经过治疗患者治愈者占56%。结论儿童嗜酸粒细胞性胃肠炎患者的临床表现及镜下表现多样,通过外周血和镜下活检发现嗜酸粒细胞计数升高是诊断儿童嗜酸粒细胞性胃肠炎的主要指标。治疗方法以激素治疗为主,同时配合使用孟鲁司特钠作为一种维持治疗的药物,可以提高治疗效果。
Objective To analyze the clinical diagnosis and treatment of childhood eosinophilic gastroenteritis. Methods 56 cases of children with eosinophilic gastroenteritis were diagnosed as children with eosinophilic gastroenteritis in our hospital from February 2013 to June 2015. The clinical manifestations, laboratory tests and serological indexes of children were comprehensively and accurately recorded. Performance and medical treatment. Results The clinical symptoms of children with eosinophilic gastroenteritis were mainly abdominal pain. The main complication was anemia. At the same time, 56 patients underwent gastrointestinal endoscopy, gastroscopy showed gastrointestinal mucosa erythema, mucosal granular change, erosion, bleeding, ulcer formation and other non-specific changes to mucosal-like changes in the majority of all children with eosinophilic gastrointestinal Patients with inflammation were given anti-Helicobacter pylori treatment, while oral montelukast sodium with treatment, after treatment of patients cured by 56%. Conclusion The clinical manifestations and microscopic appearances of children with eosinophilic gastroenteritis are various. It is found that the eosinophil count increased by peripheral blood and microscopic biopsy is the main index in diagnosis of childhood eosinophilic gastroenteritis. Treatment with hormone therapy, while using montelukast sodium as a maintenance treatment of drugs, can improve the therapeutic effect.