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目的探讨血清同型半胱氨酸(Hcy)和尿β2-微球蛋白(β2-MG)在糖尿病肾病早期诊断中的价值。方法 128例糖尿病患者,分为单纯糖尿病组和糖尿病肾病组,各64例,健康体检者64例作为对照组,检测各组Hcy和β2-MG水平。结果糖尿病肾病组Hcy和β2-MG水平均高于单纯糖尿病组和对照组,差异均有统计学意义(P<0.05);单纯糖尿病组Hcy和β2-MG水平与对照组比较,差异无统计学意义(P>0.05)。结论 Hcy和β2-MG检测对糖尿病肾病有较高的临床诊断价值,值得临床推广应用。
Objective To investigate the value of serum homocysteine (Hcy) and urinary β2-microglobulin (β2-MG) in the early diagnosis of diabetic nephropathy. Methods 128 patients with diabetes mellitus were divided into simple diabetic group and diabetic nephropathy group, 64 cases each, and 64 healthy subjects as control group. The levels of Hcy and β2-MG in each group were detected. Results The levels of Hcy and β2-MG in diabetic nephropathy group were significantly higher than those in simple diabetic group and control group (P <0.05). The levels of Hcy and β2-MG in diabetic group were not significantly different from those in control group Significance (P> 0.05). Conclusion The detection of Hcy and β2-MG has a high clinical value in the diagnosis of diabetic nephropathy, which is worthy of clinical application.