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目的 探讨鼻咽癌患者EB病毒和乙肝病毒感染的关系。方法 检测 5 0 5 1例健康者和 12 5例鼻咽癌患者的血清EBV IgA /VCA和HBsAg。 结果 健康人群的EBV IgA/VCA和HBsAg的阳性率分别为 5 .4%和 11.3 % ;健康人群EB病毒感染者的HBsAg阳性率为 9.7% ;鼻咽癌患者的EBV IgA/VCA和HBsAg的阳性率分别为 97.6 %、2 5 .6 %。鼻咽癌EB病毒、乙肝病毒双重感染率明显高于正常对照组 (P <0 .0 1) ,呈EBV IgA /VCA抗体滴度越高越容易感染HBV的倾向。 结论 双重感染可作为鼻咽癌预后判断的参数之一。
Objective To investigate the relationship between Epstein-Barr virus and hepatitis B virus infection in patients with nasopharyngeal carcinoma. Methods Serum EBV IgA / VCA and HBsAg were detected in 5 0 1 1 healthy and 125 NPC patients. Results The positive rates of EBV IgA / VCA and HBsAg in healthy population were 5.4% and 11.3%, respectively. The positive rate of HBsAg in healthy population was 9.7%. The positive rates of EBV IgA / VCA and HBsAg in nasopharyngeal carcinoma The rates were 97.6% and 25.6% respectively. The dual infection rate of EB virus and HBV was significantly higher than that of the control group (P <0.01). The higher the EBV IgA / VCA antibody titer was, the easier it was to be infected with HBV. Conclusions Double infection can be used as one of the parameters of prognosis of nasopharyngeal carcinoma.