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[目的]对照普通覆膜食管支架,观察食管内放射支架临床应用的有效性。[方法]2008~2010年间,对来自中国医学科学院北京协和医学院肿瘤医院等7家医院的71例不可手术切除食管癌患者,采用随机对照的研究方法,将其分为两组,对照组植入普通覆膜食管支架,研究组植入食管内放射支架,观察两组患者消化道梗阻缓解状况、支架周围肉芽组织增生情况、总生存期以及不良事件的发生情况。[结果]研究组患者消化道梗阻缓解状况明显优于对照组;而支架周围肉芽组织增生情况研究组则明显轻于对照组;中位生存期研究组亦明显长于对照组(145天vs 90天);研究组与对照组相比,不良事件发生率并不高于对照组。[结论]食管内放射支架临床应用安全、有效,是一种较为安全的晚期食管癌姑息治疗方法。
[Objective] To compare the effectiveness of conventional esophageal stents and esophageal stent in clinical application. [Methods] Between 2008 and 2010, 71 patients with unresectable esophageal cancer from 7 hospitals, including Peking Union Medical College Cancer Hospital, Chinese Academy of Medical Sciences, were randomly divided into two groups. The control group Into the general coated esophageal stent, the study group was implanted esophageal stent-graft to observe the two groups of patients with digestive tract obstruction relief, granulation tissue around the stent hyperplasia, overall survival and adverse events. [Results] The relief rate of digestive tract obstruction in study group was significantly better than that in control group; however, the proliferation of granulation tissue around stent group was significantly lower than that in control group; the median survival group was also significantly longer than that in control group (145 days vs 90 days ); Study group and control group, the incidence of adverse events is not higher than the control group. [Conclusion] The clinical application of esophageal stent is safe and effective. It is a safe and palliative treatment for advanced esophageal cancer.