强啡肽(Dynorphin,Dyn)是1979年Goldstein等首先从猪的垂体中发现的不同于脑啡肽和β-内啡呔的另一种内阿片肽。 一、Dyn的结构 Dyn具有一族内阿片肽,其前体不同于脑啡肽和β-内啡肽(见表1),族内各肽的氨基酸顺序(见表2)均以亮啡肽为氨基端。从17肽到8肽,不同长度的DynA片段均具Dyn活性。 Dynorphin (Dyn) is another kind of endo-opioid peptide which is different from enkephalin and β-endorphin firstly discovered by the pituitary of pig in 1979 by Goldstein et al. First, the Dyn structure Dyn has a family of opioid peptides, its precursor is different from enkephalin and β-endorphin (see Table 1), the amino acid sequence of each peptide in the family (see Table 2) Amino-terminal. From 17 peptides to 8 peptides, DynA fragments of different lengths all have Dyn activity.