本研究利用免疫胶体金技术在透射电镜下观察了５例重型流行性出血热（ＥＨＦ）患者口腔软腭标本于鳞状上皮细胞核旁、粗面内质网中、吞噬溶酶体内、细胞膜表面及细胞间隙内均观察到呈簇状、花环状、线形、串珠样排列或散在的经ＥＨＦ病毒抗体标记的胶体金颗粒，有的胶体金颗粒附着在不同形态的病毒核壳衣表面，有的金颗粒标记在病毒晶格状结构上。而在５例阴性对照片上未见特异性胶体金颗粒。此结果首次证实了口腔鳞状上皮细胞也是ＥＨＦ病毒侵袭的靶细胞。我们的发现给ＥＨＦ病毒在宿主体内提供了一个新的观察研究部位。 In this study, we observed the soft palate specimens of 5 cases of severe epidemic hemorrhagic fever (EHF) under the immunogold technique in the parasite of squamous epithelium, rough endoplasmic reticulum, phagolysin, membrane surface and cells In the gap were observed in clusters, garlands, linear, beaded like or scattered EHF virus antibody-labeled colloidal gold particles, some gold particles attached to the surface of the virus in different forms of nuclear shell coat, and some gold Particles are labeled on the viral lattice-like structure. No specific colloidal gold particles were found in 5 negative controls. This result for the first time confirms that oral squamous cells are also target cells for EHF virus invasion. Our findings give the EHF virus a new site of observation in the host.