脑血管疾病是我国死亡原因前六位重大疾病中的第一杀手,也是国际性的卫生战略重点之一。在脑血管疾病中以缺血性疾病的发病率占居首位。通常在轻度的缺氧/缺血的情况下脑的补偿机制保护中枢神经系统免受损伤,但当缺血程度加重时,便会发生不可逆性神经元损害,导致一系列的临床症状,甚至死亡。因此积极探讨缺血性神经元损伤的机制及其有效防治措施,有 Cerebrovascular disease is the number one killer in the top six major causes of death in China and one of the international health strategic priorities. In cerebrovascular disease in the incidence of ischemic diseases occupy the first place. The brain’s compensatory mechanism, which usually protects the central nervous system from injury in the general case of mild hypoxia / ischemia, irreversible neuronal damage occurs when the extent of ischemia increases, leading to a series of clinical symptoms and even death. Therefore, actively explore the mechanism of ischemic neuronal damage and effective prevention and treatment measures, there