本文将叙述1983年老化生物医学最重要的一些研究成果。 细胞生物学 组织培养中人类正常成纤维细胞的寿命有限,可使其广泛应用于衰老的研究。增殖旺盛的、继代传种早的成纤维细胞用做“年轻”细胞,而增殖力差的、继代传种晚的成纤维细胞则用做“衰老”细胞。近来,用体细胞杂交的方法探索了后一种细胞有限增殖潜力的遗传基础,将这两型细胞融合, This article will describe some of the most important findings of aging biomedical science in 1983. Cell biology The lifespan of human normal fibroblasts in tissue culture is limited, making it widely used in the study of aging. Proliferating, subcultured early fibroblasts are used as “young” cells, while fibroblasts with poor proliferative and late passages are used as “senescent” cells. Recently, the genetic basis for the limited proliferative potential of the latter cell was explored by somatic cell hybridization and the two cell types were fused.