众多证据表明,不仅原发肿瘤可出现宿主的免疫抵抗反应,转移瘤也同样受到宿主免疫反应的影响。目前认为激活的或“武装的”巨噬细胞、NK细胞和细胞毒性T细胞在肿瘤发生转移前后是宿主重要的免疫效应细胞。然而,以上结果绝大多数来自体外或动物实验,人体内观察甚少,需进一步证实。Husby应用免疫组织化学方法研究人类原发肿瘤和转移癌周围T和B淋巴细胞浸润。首先发现转移癌旁与原发癌旁浸润的淋巴细胞有所不同,大多数以B细胞浸润为主。但因其例数所限,未予定论。本文目的在于分析转移癌间质浸润的淋巴细胞是否属抗体产生细胞,以 Numerous evidence indicates that not only primary tumors but also host immune responses are present, and metastases are also affected by host immune responses. It is currently believed that activated or “armed” macrophages, NK cells and cytotoxic T cells are important immune effector cells of the host before and after tumor metastasis. However, the vast majority of the above results are from in vitro or animal experiments and are rarely observed in humans and need further confirmation. Husby used immunohistochemistry to study T and B lymphocyte infiltration around human primary tumors and metastatic cancers. Firstly, it was found that there was a difference between paracancerous paracancerous lymphocytes and primary lymphomas, most of which were B-cell infiltration. However, due to the limited number of cases, no conclusions have been reached. The purpose of this article is to analyze whether lymphocytes infiltrating into cancerous mesenchyma are antibody-producing cells.