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目的探讨PTEN基因与结直肠癌发生、发展,侵袭转移的关系。方法结直肠癌手术切除标本96例,采用免疫组化SABC法染色检测。结果结直肠癌患者PTEN基因总阳性率为52.1%(50/96),癌旁组织中阳性率为80.4%(37/46),结直肠癌表达与患者年龄,性别,肿瘤大小无关,与结直肠癌组织学病理分级,Dukes分级及有无淋巴结的转移关系密切。结论PTEN基因在结直肠癌的发生、发展、侵袭转移过程中起抑制作用。
Objective To investigate the relationship between PTEN gene and the occurrence, development, invasion and metastasis of colorectal cancer. Methods 96 cases of colorectal cancer resected specimens were detected by immunohistochemical SABC staining. Results The positive rate of PTEN gene in colorectal cancer was 52.1% (50/96) and the positive rate was 80.4% (37/46) in colorectal cancer. The expression of PTEN gene in colorectal cancer was not related to the age, gender, tumor size, Rectal cancer histological grade, Dukes grade with or without lymph node metastasis are closely related. Conclusion The PTEN gene plays an important role in the development, progression and invasion and metastasis of colorectal cancer.