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应用冠状竇插管及N_2O減飽和法研究利血平对狗冠脉血流动力的作用,及对心脏功能的影响,并从动脉与冠状靜脉血內氧、葡萄糖、乳酸、丙酮酸、脂肪酸及氨基酸含量的变化,探討利血平对心肌消耗和利用这些代謝物的影响。 靜注溶剂抗坏血酸未引起冠脉循环的变化。靜注利血平0.25毫克/公斤30分钟后,动脉压逐漸降低,24小时后降低約36％,并伴有呼吸和心搏的明显減慢,冠状竇压亦降低。冠脉血流量在30分钟吋增加,24小时后減少,而冠脉阻力一致降低。对心脏血流动力作用无明显影响。正常情况下,心肌主要利用脂肪酸及糖类作为其能量来源。抗坏血酸对心肌代謝影响不大。靜注利血平30分钟,血糖升高,心肌耗氧量及乳酸消耗量增加,說明有氧代謝旺盛;24小时后心肌氧消耗量減少,冠状靜脉內乳酸/丙酮酸比值略有增高,提示心肌无氧代謝有所增强。 綜上所述,利血平对冠脉循环和心肌代謝的作用是双相的,这种变化与体內儿茶酚胺的释放和耗尽可能有关。
Coronary sinus cannulation and N 2 O desaturation study of reserpine on coronary artery blood flow and its effects on cardiac function, and arterial and coronary venous blood oxygen, glucose, lactate, pyruvate, fatty acids and Amino acid content changes, to explore the impact of reserpine on myocardial consumption and utilization of these metabolites. Intravenous solvent ascorbic acid did not cause changes in coronary circulation. After 30 minutes of intravenous reserpine 0.25 mg / kg, arterial pressure gradually decreased, about 36% after 24 hours, accompanied by a significant slowing of breathing and heart rate, coronary sinus pressure also decreased. Coronary blood flow increased at 30 minutes, decreased after 24 hours, and coronary resistance decreased consistently. No significant effect on cardiac hemodynamic effects. Under normal circumstances, the main myocardial use of fatty acids and carbohydrates as their energy source. Ascorbic acid has little effect on myocardial metabolism. Intravenous reserpine 30 minutes, elevated blood glucose, myocardial oxygen consumption and increased lactate consumption, indicating strong aerobic metabolism; 24 hours after myocardial oxygen consumption decreased, the coronary venous lactate / pyruvate ratio increased slightly, suggesting Myocardial anaerobic metabolism has been enhanced. In summary, the effect of reserpine on coronary circulation and myocardial metabolism is biphasic, this change may be related to the release and depletion of catecholamines in the body.