肝细胞癌(HCC)是一种比较常见的全球性癌症,可被许多不同的刺激因素诱导。Losson等在小鼠身上发现了一个肿瘤抑制基因Trim24,它可能通过调节视黄酸(RA)转录网络来特异性抑制HCC发生。RA可与许多受体结合而形成细胞核受体超家族的一部分,并通过募集大量共调节蛋白来控制转录。TR Hepatocellular carcinoma (HCC) is a relatively common global cancer that can be induced by many different stimuli. Losson et al. Found a tumor suppressor gene, Trim24, in mice that specifically inhibits HCC formation by regulating the retinoic acid (RA) transcriptional network. RA binds to many receptors to form part of the nuclear receptor superfamily and controls transcription by recruiting a large number of co-regulatory proteins. TR