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应用抗c－myc原癌基因蛋白（p62c－myc）的单抗，采用免疫组化ABC法对正常胃粘膜、胃粘膜异型增生及胃癌进行标记，发现正常胃粘膜腺体颈部偶见弱阳性表达，而胃粘膜异型增生则有较高的表达率，轻、中、重度异型增生的表达率分别为70％、100％及71．4％，三者之间无显著性意义。早期及进展期胃癌的表达率分别为38．9％和73．3％，两者相比有显著性差异（P＜0．05）。本研究结果提示p62c－myc可能参与正常胃粘膜的增殖过程，与胃癌的发生有一定关系，此基因蛋白的表达有可能作为判断胃粘膜早期癌变及胃癌生物学行为的一个有用指标。
Monoclonal antibody against c-myc proto-oncogene protein (p62c-myc) was used to label normal gastric mucosa, gastric dysplasia, and gastric cancer using immunohistochemical ABC method. It was found that the normal gastric mucosa glands were occasionally weakly positive on the neck. Expression, but gastric dysplasia has a higher expression rate, the expression rate of mild, moderate and severe dysplasia were 70%, 100% and 71.4%, respectively, there was no significant difference between the three. The expression rates of early and advanced gastric cancer were 38.9% and 73.3%, respectively, and there was a significant difference between the two (P<0.05). The results of this study suggest that p62c-myc may be involved in the proliferation of normal gastric mucosa, and has a certain relationship with the occurrence of gastric cancer. The expression of this gene protein may serve as a useful indicator to determine early gastric cancer and biological behavior of gastric cancer.