论文部分内容阅读
目的:探讨前哨淋巴结活检(SLNB)阳性乳腺癌患者非前哨淋巴结(NSLN)转移的危险因素。方法:收集2009年7月—2013年10月新疆医科大学附属肿瘤医院收治的138例SLNB阳性的乳腺癌患者临床资料,采用单因素及多因素Logistic回归分析方法研究各项临床病理因素与NSLN转移的关系。结果:单因素分析显示,原发肿瘤直径、组织学分级、前哨淋巴结转移率、前哨淋巴结转移灶最大径及脉管浸润与NSLN转移有关(均P<0.05);多因素Logistic回归分析发现,原发肿瘤直径(OR=2.263,P=0.005)、前哨淋巴结转移率(OR=1.919,P=0.002)、前哨淋巴结转移灶最大径(OR=8.479,P=0.000)、脉管浸润(OR=4.518,P=0.029)是NSLN转移的独立危险因素。结论:原发肿瘤直径、前哨淋巴结转移率、前哨淋巴结转移灶最大径及脉管浸润可作为预测乳腺癌NSLN转移的独立性指标。
Objective: To investigate the risk factors of non-sentinel lymph node (NSLN) metastasis in SLNB positive breast cancer patients. Methods: The clinical data of 138 patients with SLNB positive breast cancer who were admitted to Cancer Hospital of Xinjiang Medical University from July 2009 to October 2013 were collected. The single factor and multivariate logistic regression analysis were used to investigate the relationship between clinical and pathological factors and NSLN metastasis Relationship. Results: Univariate analysis showed that primary tumor diameter, histological grade, sentinel lymph node metastasis rate, maximum diameter of sentinel lymph node metastasis and vascular infiltration were correlated with NSLN metastasis (all P <0.05). Multivariate logistic regression analysis showed that original The tumor diameter (OR = 2.263, P = 0.005), the rate of sentinel lymph node metastasis (OR = 1.919, P = 0.002), the maximum diameter of sentinel lymph node metastasis (OR = 8.479, P = 0.000) , P = 0.029) was an independent risk factor for NSLN metastasis. CONCLUSIONS: Primary tumor diameter, sentinel lymph node metastasis rate, maximum diameter of sentinel lymph node metastasis and vascular infiltration can be used as independent predictors of NSLN metastasis in breast cancer.