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目的 探讨三氧化二砷（ Ａｓ２ Ｏ３ ）在 Ｓｃｉｄ 小鼠体内的移植瘤抑制作用及可能作用机理。方法 将体外培养的人舌鳞癌细胞系 Ｔｃａ８１１３ 细胞接种于 Ｓｃｉｄ 小鼠皮下，建立移植瘤模型，观察 Ａｓ２ Ｏ３ 对 Ｔｃａ８１１３ 细胞移植瘤的抑瘤效果。结果 Ａｓ２ Ｏ３ 对 Ｔｃａ８１１３ 细胞移植瘤的抑制率为４９１６％ ，且存在较明显的诱导细胞凋亡作用。结论 Ａｓ２ Ｏ３ 可能对口腔鳞癌有较好的治疗作用。
Objective To investigate the inhibitory effect of arsenic trioxide (As2 O3) on the xenografts of Scid mice and its possible mechanism. Methods Human tongue squamous cell carcinoma cell line Tca8113 cultured in vitro was inoculated subcutaneously into Scid mice to establish a model of xenograft tumor. The inhibitory effect of As2 O3 on Tca8113 cell xenograft tumor was observed. Results The inhibitory rate of as2 O3 on Tca8113 cell xenografts was 4916%, and there was obvious apoptosis-inducing effect. Conclusion As2 O3 may have a good therapeutic effect on oral squamous cell carcinoma.