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目的：观察甲硝唑根管消毒控释系统（ＣＲＤＧＭ）治疗根尖周病的疗效及体内抑菌情况。方法：对封甲醛甲酚两次以上仍有症状的患牙改封ＣＲＤＧＭ；对急性期患牙根管内封ＣＲＤＧＭ，以口服甲硝唑对照；根管治疗一次法分ＣＲＤＧＭ及牙胶尖根充两组；将ＣＲＤＧＭ封入单根管患牙内，治疗前后根管内取样作厌氧培养，以甲醛甲酚对照。结果：９３．３％的患牙根尖症状消失；两组在控制急性症状上无差异；ＣＲＤＧＭ根充组术后不良反应及急性症状发生率明显低于牙胶尖组；随着时间延长ＣＲＤＧＭ组根管内厌氧菌检出率明显低于甲醛甲酚组。结论：ＣＲＤＧＭ作根管消毒剂及根充材料有良好的抗感染能力。
OBJECTIVE: To observe the curative effect and antibacterial activity of metronidazole root canal disinfection and controlled release system (CRDGM) in the treatment of periapical periodontitis. Methods: CRDGM was used to seal the tooth with two or more camptothecin, and CRDGM was given to the root canal in the acute phase. Oral administration of metronidazole was used as the control. One point method of root canal treatment for CRDGM and gutta percha was added The CRDGM was implanted into the root canal of a single canal, and the anterior root canal was sampled for anaerobic culture before and after treatment. Formaldehyde cresol control. RESULTS: 93.3% of the apical symptoms disappeared. There was no difference in the control of acute symptoms between the two groups. The postoperative adverse reactions and the incidence of acute symptoms in the CRDGM group were significantly lower than those in the dentin group. With the prolongation of the CRDGM group The detection rate of anaerobic bacteria in root canal was significantly lower than that of formaldehyde cresol group. Conclusion: CRDGM has good anti-infection ability as root canal disinfectant and root filling material.