本文采用固相合成法制备缓激肽(BK)、赖氨酰缓激肽(KD)、T-激肽、[羟基脯氨酸~3]-缓激肽([Hyp~3]-BK)和几种类似物,并用HPLC 方法纯化。为了测定它们对BK_2和BK_1受体的活性,实验测定了它们对狗颈动脉和肾动脉的舒张能力以及对兔颈静脉和动脉的收缩能力,其中前三种材料属BK_4受体,兔颈动脉为BK_1受体,去内皮的狗肾动脉也属BK_1受体。结果表明,在3种BK_2受 In this paper, BK, L-kinin, [Hyp ~ 3] -BK) And several analogues and purified by HPLC method. To determine their activity on BK_2 and BK_1 receptors, their ability to relax the carotid and renal arteries of dogs and their contractile ability to the jugular and arterial arteries of rabbits were experimentally determined. The first three materials were BK_4 receptors, rabbit carotid arteries The BK_1 receptor, the endothelium of the dog’s renal artery is also a BK_1 receptor. The results show that the three BK_2 are affected