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以Sertoli细胞之间的紧密连接为主要形态学基础的血睾屏障对维持正常的生精过程有着重要的生理意义。它能阻止大分子物质进入生精上皮的近管脑部,并阻止雄性激素结合蛋白ABP及与其结合着的雄性激素外逸。从而保证近管腔部的生精过程在一个相当稳定而适宜的微环境中进行。实验性隐睾及温热因素的作用下,首先受到损伤的是近管腔部的生精细胞,提示血睾屏障可能有变化。本实验采用2％硝酸镧作示踪物,以0.1ml注入睾丸间质内,对实验性隐睾的第1天、2天、3天、6天、12天和38天组等不同阶段的大鼠血睾屏障进行电镜观察。
The close association of Sertoli cells as the major morphological basis of the blood-testis barrier has important physiological implications for maintaining normal spermatogenesis. It prevents macromolecules from entering the proximal brain of the seminiferous epithelium and prevents the androgen-binding protein ABP from binding to its androgen. Thus ensuring that the process of spermatogenesis in the proximal lumen is performed in a fairly stable and suitable microenvironment. Experimental cryptorchidism and the role of warming factors, the first damage is near the lumen of spermatogenic cells, suggesting that the blood testis barrier may have changed. In this experiment, 2% lanthanum nitrate was used as a tracer to inject testis into the testicular interstitium in 0.1ml. The experimental cryptorchid test was performed in different stages of day 1, day 2, day 3, day 6, day 12 and day 38 Rat blood testis barrier was observed by electron microscopy.