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目的探讨抽动障碍(TD)儿童血清TNF-α和IL-6的表达。方法选取TD患儿200例作为观察组,50例非TD儿童作为对照组,检测两组血清TNF-α和IL-6水平,分析TD患儿美国耶鲁综合抽动严重程度量表(YGTSS)评分、年龄与血清TNF-α和IL-6水平的相关性。结果观察组血清TNF-α水平高于对照组(P<0.05),两组IL-6水平差异无统计学意义(P>0.05)。TNF-α水平与YGTSS评分呈正相关(r_s=0.949,P<0.05),与年龄呈负相关(r_s=-0.344,P<0.05),尚未发现IL-6水平与YGTSS评分、年龄存在相关关系(P>0.05)。结论 TD患儿体内存在一定程度的炎症反应,且与患儿病情严重程度、年龄有关。
Objective To investigate the expression of serum TNF-α and IL-6 in children with tic disorder (TD). Methods Totally 200 children with TD were selected as the observation group and 50 non-TD children as the control group. Serum levels of TNF-α and IL-6 were measured in both groups. The Yale tic tactility scale (YGTSS) Age and serum TNF-α and IL-6 levels in the correlation. Results The level of serum TNF-α in the observation group was higher than that in the control group (P <0.05). There was no significant difference between the two groups in the level of IL-6 (P> 0.05). The level of TNF-αwas positively correlated with YGTSS score (r_s = 0.949, P <0.05), and was negatively correlated with age (r_s = -0.344, P <0.05). There was no correlation between IL-6 level and YGTSS score and age P> 0.05). Conclusion There is a certain degree of inflammatory reaction in children with TD and is related to the severity and age of children.